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Tumour Regression via Integrative Regulation of Neurological, Inflammatory, and Hypoxic Tumour Microenvironment

Biomolecules & Therapeutics 2020년 28권 2호 p.119 ~ 130
이창훈 ( Lee Chang-Hoon ) - Dongguk University College of Pharmacy

조정숙 ( Cho Jung-Sook ) - Dongguk University College of Pharmacy
조정숙 ( Cho Jung-Sook ) - Dongguk University College of Pharmacy
이경 ( Lee Kyeong ) - Dongguk University College of Pharmacy

Abstract


Changing trends in anticancer research have altered the treatment paradigm to the extent that it is difficult to investigate any anticancer drugs without mentioning immunotherapy. Thus, we are finally contemplating tumour regression using magic bullets known as immunotherapy drugs. This review explores the possible options and pitfalls in tumour regression by first elucidating the features of cancer and the importance of tumour microenvironments. Next, we evaluated the trends of anticancer therapeutics regulating tumour microenvironment. Finally, we introduced the concept of tumour regression and various targets of tumour microenvironment, which can be used in combination with current immunotherapy for tumour regression. In particular, we emphasize the importance of regulating the neurological manifestations of tumour microenvironment (N) in addition to inflammation (I) and hypoxia (H) in cancer.

키워드

Immunotherapy; Tumour regression; Tumour microenvironment; Neurological; Inflammation; Hypoxia
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