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The Effect of Aerobic Exercise Training Versus Resveratrol Supplementation on Mitochondrial Biogenesis in Skeletal Muscle of High-fat Diet-induced Obese Mice

Journal of Life Science 2019년 29권 8호 p.837 ~ 845
 ( Kim Kyung-Il ) - Chungnam National University Department of Sports Sciences

 ( An Sang-Min ) - Korea University Department of Sport and Leisure Studies
 ( Park Hee-Geun ) - Chungnam National University Department of Sports Sciences
 ( Lee Wang-Lok ) - Chungnam National University Department of Sports Sciences

Abstract


The purpose of this study was to analyze the effects of aerobic exercise and resveratrol supplementation on mitochondrial biogenesis in skeletal muscle of high-fat diet-induced obese mice. In this study, 4-wk-old C57BL/6 male mice were divided into four groups, with 10 animals in each group: a normal diet group (NC), high-fat diet group (HC), high-fat diet group with resveratrol supplementation (HRe), and high-fat diet GROUP with exercise (HE). Aerobic exercise was performed on a treadmill for 40~60 min/d at 10~14 m/min, 0% grade, 4 d/wk for 16 wk. Resveratrol (25 mg/kg bodyweight) was administrated once a day, 4 d/wk for 16 wk. There was a significance difference in COX-IV mRNA expression in the NC group versus that in the HC group (p<0.05). The expression of the SIRT-3, PGC- 1a, and COX-IV mRNA genes in the HE group increased significantly as compared with the expression of these genes in the HC and HRe groups (p<0.05). These results indicated that high- fat diet-induced obesity did not affect mitochondria biogenesis gene expression in skeletal muscle. In contrast, aerobic exercise training increased the expression of mitochondria biogenesis gene expression in skeletal muscle in high-fat diet-induced obese mice. These findings suggested that aerobic exercise but not resveratrol supplementation had a positive effect on mitochondrial biogenesis in skeletal muscle in high-fat diet-induced obese mice.

키워드

Aerobic exercise; mitochondrial biogenesis; obese; resveratrol; skeletal muscle
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