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미세먼지와 눈건강

Fine dust and eye health

대한의사협회지 2019년 62권 9호 p.486 ~ 494
최수연 ( Choi Soo-Youn ) - 고려대학교 의과대학 안과학교실

엄영섭 ( Eom Young-Sub ) - 고려대학교 의과대학 안과학교실
송종석 ( Song Jong-Suk ) - 고려대학교 의과대학 안과학교실
김효명 ( Kim Hyo-Myung ) - 고려대학교 의과대학 안과학교실

Abstract


There are no drugs without the risk of potential adverse reactions. All pharmacologically active substances can cause adverse drug reactions (ADRs). This paper aims at introducing recent trends in pharmacosurveillance systems for ADRs, which can be broadly classified into type A and B reactions. Since type A reactions are associated with drug pharmacology, they are usually dose-dependent and predictable. Whereas, type B reactions occur in some susceptible individuals, regardless of the pharmacological action of drug. Drug hypersensitivity reactions are typical examples of type B reactions and are subclassified according to the underlying pathomechanism. Recent advancements in pharmacogenomics have enlightened the understanding of individual differences in drug efficacy and susceptibility to ADRs. Therefore, expectations for safe personalized medicines are higher than ever before. However, premarketing clinical trials are too small and too short to uncover rare but serious ADRs and detect long-standing ADRs. In the past, post-marketing surveillance systems mainly focused on passive ADR monitoring systems, based on spontaneous reports. Recently, the importance of active pharmacovigilance systems, which use big data, is growing with recent advancements in medical informatics. Thus, regarding ADRs, suspecting and detecting the causative drug using causality assessment based on data science may contribute to decrease suffering induced by ADRs.

키워드

대기오염; 환경; 먼지; 눈; 건강
Air pollution; Environment; Dust; Eye; Health
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