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Cyclophosphamide에 의해 유도된 면역저하 마우스 모델에서 홍도라지 추출물의 면역 기능 조절 효과

Aged Doraji (Platycodon grandiflorum) Ameliorates Cyclophosphamide-Induced Immunosuppression in Mice

생약학회지 2019년 50권 3호 p.219 ~ 225
최지혜 ( Choi Ji-Hye ) - 농촌진흥청 국립농업과학원

이은별 ( Lee Eun-Byeol ) - 농촌진흥청 국립농업과학원
박양규 ( Park Yang-Gyu ) - 농촌진흥청 국립농업과학원
이혜경 ( Lee Hye-Kyung ) - 농촌진흥청 국립농업과학원
장환희 ( Jang Hwan-Hee ) - 농촌진흥청 국립농업과학원
최정숙 ( Choe Jeong-Sook ) - 농촌진흥청 국립농업과학원
황경아 ( Hwang Kyung-A ) - 농촌진흥청 국립농업과학원
박신영 ( Park Shin-young ) - 농촌진흥청 국립농업과학원
황인국 ( Hwang In-Guk ) - 농촌진흥청 국립농업과학원
홍하철 ( Hong Ha-Cheol ) - 농촌진흥청 국립농업과학원
이해정 ( Lee Hae-Jeung ) - 가천대학교 식품영양학과
정현철 ( Jeong Hyun-Cheol ) - SK바이오랜드 식품연구소
김현주 ( Kim Hyun-Ju ) - 세계김치연구소
이성현 ( Lee Sung-Hyen ) - 농촌진흥청 국립농업과학원

Abstract


This study was done to examine immunomodulative effects of aged doraji (AD) in the immune-suppressed mice induced by cyclophosphamide. The immune-stimulating effects of ethanol AD extract in in vivo at 75 and 150 mg/kg body weight (BW) for AD and 2AD groups were evaluated and compared to the normal doraji group (2ND, 150 mg/kg BW) treated with a doraji without aging process. After the 10 days of oral supplement, body and immune related organ weights, serum immunoglobulin G (IgG) and cytokines levels, splenocytes proliferation rate, and splenic NK cell activity were measured as immune-related biomarkers. Body weight and serum IgG level increased in the 2AD group. But, the serum Th2 cytokine (IL-6, TNF-a) levels were lower in the AD and 2AD groups, respectively. Splenic T cell and B cell proliferation and NK cell activity increased in the doraji groups and the significant increases were found only in the 2AD group. Thus, the aged doraji extract may affect body weight, serum IgG level, splenocytes proliferation, and splenic NK cell activity, and normalize the Th2 cytokine levels in the immune-suppressed mice. The results suggest that the aged doraji improves effectively immune system rather than the normal one.

키워드

Platycodon grandiflorum; Immune; Splenocyte proliferation; Serum cytokine; NK cell activity
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