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영지버섯(Ganoderma lucidum)으로 부터 분리한 이차대사산물 및 이들의 항 염증 활성

Secondary Metabolites Isolated from Ganoderma lucidum and Their Anti-inflammatory Activity

생약학회지 2019년 50권 3호 p.232 ~ 238
김혜지 ( Kim Hye-Ji ) - 극지연구소 극지유전체사업단

구만형 ( Koo Man-Hyung ) - 극지연구소 극지유전체사업단
이준혁 ( Lee Jun-Hyuck ) - 극지연구소 극지유전체사업단
서승석 ( Seo Seung-Suk ) - 목포대학교 생명과학과
윤의중 ( Youn Ui-Joung ) - 극지연구소 극지생명과학연구부

Abstract


Phytochemical study of Ganoderma lucidum (Polyporaceae) let to the isolation of five lanostane triterpenoid (1-5), along with two nitrogen derived phenolic compounds, N-phenylethylformamide (6) and N-acetylphenethylamine (7). The structures of the compounds were determined by 1D and 2D NMR, and MS experiments, as well as by comparison of their data with published values. Compounds 6 and 7 were isolated for the first time from the genus Ganoderma and this species. All the compounds were evaluated for cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production induced by lipopolysaccharide (LPS) in mouse macrophage RAW 264.7 cells in vitro. Among the isolates, compounds 2 and 3 showed moderate inhibitory activity against NO production.

키워드

Ganoderma lucidum; Polyporaceae; Lanstane triterpenoid; Anti-inflammatory
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