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왕모시풀의 페놀성 성분 및 항당뇨 활성

Phenolic Constituents of Boehmeria pannosa and α-Glucosidase Inhibitory Activity

생약학회지 2019년 50권 4호 p.239 ~ 244
류세환 ( Ru Se-Hwan ) - 충북대학교 약학대학

김선범 ( Kim Seon-Beom ) - 충북대학교 약학대학
연상원 ( Yeon Sang-Won ) - 충북대학교 약학대학
투르크 아이만 ( Turk Ayman ) - 충북대학교 약학대학
조양희 ( Jo Yang-Hee ) - 충북대학교 약학대학
황방연 ( Hwang Bang-Yeon ) - 충북대학교 약학대학
안미정 ( Ahn Mi-Jeong ) - 경상대학교 약학대학
이미경 ( Lee Mi-Kyeong ) - 충북대학교 약학대학

Abstract


Boehmeria pannosa (Urticaceae) is a perennial herb widely distributed in Korea. In this study, investigation on the constituents of B. pannosa was conducted by chromatographic techniques and spectroscopic analysis. As a result, nine compounds including eight phenolic compounds, 3-hydroxy-1-(4-hydroxyphenyl)propan-1-one (1), b-hydroxypropiovanillone (2), C-veratroylglycol (3), 3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-propan-1-one (4) 2,3-dihydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl) -1-propanone (5), p-coumaric acid (6), 4-hydroxybenzoic acid (7), vanillic acid (8) and one lignan, (-)-(7R,8S)-dihydrodehydrodiconiferyl alcohol (9) were isolated from the EtOAc-soluble fraction of B. pannosa. Among them, compounds 5, 6 and 9 inhibited a-glucosidase inhibitory activity more than 50% at the concentration of 100 μM.

키워드

Boehmeria pannosa; a-Glucosidase; Phenolic; Lignan; Diabetes
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