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암세포 성장 저해 및 항염증 효능을 나타내는 산여뀌 성분의 분리

Isolation of the Constituents with Cancer Cell Growth Inhibition and Anti-inflammatory Activity from Persicaria nepalensis

생약학회지 2019년 50권 4호 p.245 ~ 252
김동화 ( Kim Dong-Hwa ) - 서울대학교 약학대학

이상국 ( Lee Sang-Kook ) - 서울대학교 약학대학
박희준 ( Park Hee-Juhn ) - 상지대학교 제약공학과

Abstract


This study was initially explored to procure biomaterials capable of inhibiting cancer cell growth from nine Persicaria species (Polygonaceae). The extract of P. nepalensis that was selected from the initial screenings was further fractionated to identify bioactive compounds. The ethyl acetate (EtOAc) fraction was shown to be the most active in the inhibition of cell growth against six cancer cell lines (IC50 value of 3.77?12.87 μg/ml). Phytochemical study led to the isolation of two galactolipids of 1,2-di-O-linolenoyl-3-O-β-D-galactospyranosyl-sn-glycerol (1) and 1-O-linolenoyl-3-O-β-D-galactospyranosyl-sn-glycerol (2) from the hexane fraction and three phenylpropanoyl sucroses of lapathoside A (3), vanicoside B (4) and lapathoside C (5) from the EtOAc fraction. These isolated compounds have not been reported from this plant. Compounds 3 and 4 exhibited the effective growth inhibition against a panel of cancer cell lines (IC50 value of 6.90?18.09 μM). In addition, the anti-inflammatory activity was evaluated to determine lipopolysaccharide (LPS)-induced nitric oxide (NO) formation in RAW264.7 mouse macrophage cells. The EtOAc fraction (IC50; 34.14 μg/ml) and its constituents, 3 (8.55 μM) and 4 (7.83 μM) were shown to be effective in the inhibition of LPS-induced NO production. Therefore, compounds 3 and 4 were considered to be active constituents for anti-inflammatory and antitumor activity from P. nepalensis.

키워드

Persicaria nepalensis; Polygonaceae; Galactolipids; Phenylpropanoyl sucroses; Cancer cell growth; Inflammation
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