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스코폴라민으로 유도한 기억력 장애 동물모델에서 명자나무 (Chaenomeles speciose Nakai) 과실 추출물의 효과

Effects of Chaenomeles speciose Nakai on Scopolamine Induced Memory Impaired Mouse Model

생약학회지 2019년 50권 4호 p.253 ~ 259
김지현 ( Kim Ji-Hyun ) - 경희대학교 나노의약생명과학과, 생물학과

김란희 ( Kim Ran-Hee ) - 경희대학교 나노의약생명과학과, 생물학과
김재훈 ( Kim Jae-Hoon ) - 경희대학교 나노의약생명과학과, 생물학과
임미경 ( Lim Mi-Kyung ) - 고려은단
이상호 ( Lee Sang-Ho ) - 고려은단
한은혜 ( Han Eun-Hye ) - 고려은단
장대식 ( Jang Dae-Sik ) - 경희대학교 나노의약생명과학과, 생물학과
류종훈 ( Ryu Gong-Hun ) - 경희대학교 나노의약생명과학과, 생물학과

Abstract


Chaenomeles speciose Nakai (CSP) or Chaenomeles sinensis Koehne (CSS) (Rosaceae) has been used, traditionally, to treat muscle problems and gastric dampness in eastern Asia countries. Therefore, many studies have focused on investigating its active compounds and effects on muscle pain, arthritis and gastro-intestinal diseases. Recently, several studies reported that CSS extract degrade amyloid plaques and enhance synaptic acetylcholine level in vivo and in vitro. Although these two Chaenomeles species are used without differences, CSP is reported to contains more phenolic compounds which are known to enhance memory. Therefore, in this study, we investigated the memory ameliorating effects of CSP by employing the passive avoidance test, Y-maze task and novel object recognition test. CSP (30 or 100 mg/kg) ameliorated the declined memory induced by scopolamine injection and enhanced the brain-derived neurotrophic factor (BDNF) levels along with post synaptic density protein 95 (PSD 95) levels at the hippocampus of the scopolamine-injected mouse brain. These results suggested that CSP alleviates the cognition declines caused by cholinergic blockade via enhancing BDNF levels and PSD 95, and that it would enhance memory formation and be useful for treating memory declines.

키워드

Chaenomeles speciosa; Alzheimer’s disease; Memory declines; Brain-derived neurotrophic factor (BDNF)
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