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Sprague-Dawley 랫드를 이용한 땃두릅나무 열수추출물 분말의 13주 반복 경구투여 독성에 관한 연구

Thirteen Weeks Repeated Oral Dose Toxicity Study of Oplopanax elatus (Nakai) Nakai Hydrothermal Extract Powder in Sprague-Dawley Rats

생약학회지 2019년 50권 4호 p.260 ~ 271
유남호 ( Yoo Nam-Ho ) - 강원대학교 농업생명과학대학

권용수 ( Kwon Yong-Soo ) - 강원대학교 약학대학
천현수 ( Chun Hyeon-Soo ) - (주)에이치티오라이프
안규섭 ( Ahn Kyu-Sup ) - 한국건설생활환경시험연구원
김혜진 ( Kim Hye-Jin ) - 한국건설생활환경시험연구원
류현열 ( Ryu Hyeon-Yeol ) - 한국건설생활환경시험연구원
이소민 ( Lee So-Min ) - 한국건설생활환경시험연구원
송경석 ( Song Kyung-Seuk ) - 한국건설생활환경시험연구원
박병준 ( Park Byung-Jun ) - 강원대학교 농업생명과학대학
김명조 ( Kim Myong-Jo ) - 강원대학교 농업생명과학대학

Abstract


This study aimed to evaluate the safety of Oplopanax elatus (Nakai) Nakai hydrothermal extract powder. It was conducted using male and female Sprague-Dawley (SD) rats. The test group was established with dose of 500 (low-dosage group), 1,000 (medium- dosage group), and 2,000 (high- dosage group) mg/day. These are investigated that number of dead animals, general symptoms, weight changes, food consumption, ophthalmological examination, urinalysis, urine volume, hematological values, plasma coagulation time values, serum biochemical values, absolute organ weight, relative organ weight and histopathological finding during the experiment. As a result of the above, toxicological changes were not observed. Therefore, the non-toxic content of Oplopanax elatus (Nakai) Nakai hydrothermal extract powder is determined to be 2,000 mg/kg/day, and target organ was not observed.

키워드

Dose; Oplopanax elatus (Nakai) Nakai; Oral; Rat; Toxicity
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