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Anti-nociceptive activity of Corylopsis gotoana

생약학회지 2019년 50권 4호 p.272 ~ 276
박지원 ( Park Zi-Won ) - 우석대학교 약학대학

안순영 ( An Soon-Young ) - 우석대학교 약학대학
윤선화 ( Yoon Seon-Hwa ) - 우석대학교 약학대학
신윤철 ( Shin Youn-Chel ) - 우석대학교 약학대학
이세연 ( Lee Se-Yeoun ) - 우석대학교 약학대학
차동석 ( Cha Dong-Seok ) - 우석대학교 약학대학
전훈 ( Jeon Hoon ) - 우석대학교 약학대학

Abstract


Corylopsis gotoana has been widely used as a traditional medicine for the treatment of lots of disease including cold, edema and vomiting. However pharmacological and phytochemical studies on the C. gotoana are extremely limited. Here in this study, the author investigated the anti-nociceptive effects of the methanolic extract of Corylopsis gotoana (MCG) using various pain models. In the present study, MCG exhibited strong and dose-dependent anti-nociceptive activities on various experimental pain models including thermal nociception and chemical nociception, compared to positive control such as tramadol and indomethacin. In addition, the result from combination test using naloxone, analgesic activity of MCG was slightly reduced, indicating that MCG acts as a partial opioid receptor agonist. These results demonstrated that MCG has potent analgesic potential and thus it may be possibly used as a valuable anti-nociceptive agent.

키워드

Corylopsis gotoana; Anti-nociception; Opioid receptor agonist
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