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소리쟁이(Rumex crispus) 추출물의 제1형 알레르기 반응 억제 효과

Rumex crispus Suppresses Type I Hypersensitive Immune Response

생약학회지 2019년 50권 4호 p.277 ~ 284
고은교 ( Ko Eun-Kyo ) - 덕성여자대학교 약학대학

김영미 ( Kim Young-Mi ) - 덕성여자대학교 약학대학

Abstract


Rumex crispus is known to have anticancer, antioxidant, antibacterial, and bone loss inhibitory activities. Mast cells are critical immune cells that induce a type 1 IgE-mediated allergic reaction. However, there are no reports of inhibitory effects of Rumex crispus on mast cells and allergic reactions. In this study, we performed some experiments to investigate whether Rumex crispus ethanol extract(RCE) has any inhibitory effect on antigen-induced type I allergic response in vitro and in vivo. RCE inhibited degranulation of IgE-mediated mast cells(IC50, ~57 μg/ml) and cytokine production such as TNF-a and IL-4 in a dose-dependent manner. In vivo, RCE significantly inhibited passive cutaneous anaphylaxis(PCA)(ED50, ~198 mg/kg) in mice. Furthermore, RCE inhibited degranulation of MCs in ear tissue of mice with PCA. Mechanism studies showed that RCE inhibited the activation of Syk and Syk-dependent pathway such as LAT, PLC-g, Akt, and MAP Kinase. Our results demonstrate for the first time that RCE inhibits type I hypersensitive response by suppressing the activity of Syk in mast cells, thereby reducing degranulation and cytokine production. Taken together, RCE could be used as a novel therapeutic material to suppress allergic diseases.

키워드

Rumex crispus extract(RCE); Mast cells; Allergy; Anti-allergic effect; Syk
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