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자외선 조사에 의해 노화된 섬유아세포에서 Cycloheterophyllin의 항노화 효능

Anti-aging Effect of Cycloheterophyllin in UVA-irradiated Dermal Fibroblasts

생약학회지 2019년 50권 4호 p.285 ~ 290
심중현 ( Shim Joong-Hyun ) - 세명대학교 화장품뷰티생명공학부

Abstract


This study was carried out to identify the skin anti-aging effect of cycloheterophyllin on dermal fibroblasts. To elucidate anti-aging effects of cycloheterophyllin on dermal fibroblasts, I measured cell viability, mRNA expressions, and Collagen, type I/matrix metallopeptidase 1(MMP1)-ELISA assay. In this study, I investigated the effects of cycloheterophyllin on Collagen, type I, alpha 1(COL1A1)/Collagen, type III, alpha 1(COL3A1)/MMP1/Superoxide dismutases/Catalase(CAT) mRNA expressions and Collagen, type I/MMP1 protein production. Quantitative Real-time RT-PCR showed that cycloheterophyllin increased mRNA level of COL1A1/COL3A1/CAT genes and collagen, type I protein by ELISA assay compared to UVA-treated dermal fibroblasts. Furthermore MMP1 mRNA and protein expressions were decreased by cycloheterophyllin treatment. These observations revealed that cycloheterophyllin increased anti-aging effects in dermal fibroblasts. Therefore, I identified the anti-aging effects of cycloheterophyllin, and these results showed that the cycloheterophyllin can be a considerable potent ingredient for skin anti-aging. Based on this, I anticipated further researches about cycloheterophyllin for mechanism to develop not only cosmetics but for healthcare food or medicine.

키워드

Cycloheterophyllin; Anti-aging; Collagen; type I; alpha 1; Matrix metallopeptidase 1; Collagen; type III; alpha 1; Catalse
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