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꽃잔디 메탄올 추출물의 RAW264.7 대식세포와 BV2 미세아교세포에서의 항염증 효과

Anti-inflammatory Effects of the Methanol Extracts of Phlox subulata on LPS-induced RAW264.7 Macrophages and BV2 Microglia

생약학회지 2019년 50권 4호 p.291 ~ 298
김관우 ( Kim Kwan-Woo ) - 원광대학교 약학대학

이정 ( Li Jing ) - 원광대학교 약학대학
이환 ( Lee Hwan ) - 조선대학교 약학대학
이동성 ( Lee Dong-Sung ) - 조선대학교 약학대학
오현철 ( Oh Hyun-Cheol ) - 원광대학교 약학대학
김윤철 ( Kim Youn-Chul ) - 원광대학교 약학대학

Abstract


Phlox subulata is a perennial herbaceous flower and is a member of the Polemoniaceae family. This plant is known to resist to various stresses including salt, drought, heat, and cold stresses. In this investigation, we evaluated the ant-inflammatory effect of the methanolic extract of P.subulata(PSM) on lipopolysaccharide(LPS)-induced RAW264.7 macrophages and BV2 microglia. PSM reduced the production of nitric oxide(NO) in LPS-stimulated both RAW264.7 and BV2 cells, but did not affect to the production of prostaglandin E2(PGE2). It inhibited the expression of inducible nitric oxide synthase(iNOS) and cyclooxygenase(COX)-2 in both cells. In addition, PSM suppressed the production of pro-inflammatory cytokines including interleukin(IL)-6 and tumor necrosis factor(TNF)-a. These inhibitory effects were contributed by inactivation of nuclear factor kappa B(NF-κB) and mitogen-activated protein kinases(MAPKs) pathways by PSM. Thus, these results suggested that P.subulata can be a candidate material to treat inflammatory diseases.

키워드

Phlox subulata; Lipopolysaccharide; Inflammation; RAW264;7 macrophage; BV2 microglia
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