medric medric
[닫기]
잠시만 기다려 주세요. 로딩중입니다.

Albizzia julibrissin Suppresses Testosterone-induced Benign Prostatic Hyperplasia by Regulating 5α-Reductase Type 2 - Androgen Receptor Pathway

Natural Product Sciences 2019년 25권 3호 p.200 ~ 207
 ( Hong Geum-Lan ) - Chungnam National University Department of Veterinary Medicine

 ( Kim Hyun-Tae ) - Institute for Basic Science Center for Vascular Research
 ( Park Se-Ra ) - Samsung Biomedical Research Institute
 ( Lee Na-Hyun ) - Chungnam National University Department of Veterinary Medicine
 ( Ryu Kyung-A ) - Chungnam National University Department of Veterinary Medicine
 ( Kim Tae-Won ) - Chungnam National University Department of Veterinary Medicine
 ( Song Gyu-Yong ) - Chungnam National University Department of Pharmacy
 ( Jung Ju-Young ) - Chungnam National University Department of Veterinary Medicine

Abstract


Albizzia julibrissin (AJ) is an herbal medicine that shows low toxicity, promotes promoting blood circulation and mitigates the inflammation and has mild side effects. Benign prostate hyperplasia (BPH) is one of the most common diseases that occurs in older males and often results in lower urinary tract symptoms. This study was conducted to evaluate the protective effect of AJ against BPH using LNCaP cells and Sprague Dawley rats treated with testosterone. Treatment with AJ extract reduced the expression of androgen receptor (AR) and prostate-specific antigen (PSA) in vitro. In vivo, rats were divided into 6 groups: 1 (Normal Control); 2 (Testosterone propionate (TP) alone); 3 (TP + finasteride); 4 (TP + AJ 10 mg/kg); 5 (TP + AJ 50 mg/kg); 6 (TP + AJ 300 mg/kg). The groups treated with AJ showed reduced the relative prostate weights and BPH-related proteins were altered, with decreased AR, PSA and proliferating cell nuclear antigen (PCNA) observed by western blot. Histopathological analysis revealed the therapeutic effect of AJ, with a decreased thickness of epithelial cells and reduced level of PCNA and 5α-reductase type 2. These results suggest that AJ extract could ameliorate testosterone-induced benign prostatic hyperplasia.

키워드

Benign prostate hyperplasia; Albizzia julibrissin; 5α-reductase type 2; androgen receptor; proliferating cell nuclear antigen
원문 및 링크아웃 정보
등재저널 정보
KCI