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Xylaroisopimaranin A, a New Isopimarane Derivative from an Endophytic Fungus Xylaralyce sp

Natural Product Sciences 2019년 25권 3호 p.228 ~ 232
 ( Bao Shang-Song ) - China Three Gorges University College of Biological and Pharmaceutical Science

 ( Liu Hui-Hui ) - China Three Gorges University College of Biological and Pharmaceutical Science
 ( Zhang Xue-Qing ) - China Three Gorges University College of Biological and Pharmaceutical Science
 ( Liu Cheng-Xiong ) - China Three Gorges University College of Biological and Pharmaceutical Science
 ( Li Xiao-Cong ) - China Three Gorges University College of Biological and Pharmaceutical Science
 ( Guo Zhi-Yong ) - China Three Gorges University College of Biological and Pharmaceutical Science

Abstract


Five secondary metabolites, including a new isopimarane derivative xylaroisopimaranin A (1), were isolated from the endophytic fungus Xylaralyce sp. (HM-1), and their structures were elucidated by 1D, 2D NMR, MS and CD spectra. Their bioactivities were performed to antibacterial, Hep G2 cells cytotoxicity and brine shrimp inhibition. The biological evaluation results showed that the xylaroisopimaranin A (1), xylabisboein B (2), griseofulvin (3) , 5-methylmellein (4) and mellein-5-carboxlic acid (5) displayed no significant Hep G2 cells cytotoxicity and antibacterial acitivity, but they inhibited the brine shrimp with IC50 from 0.5 to 25 μmol/mL.

키워드

Endophytic fungus; Xylaralyce sp.; Structural elucidation; Brine shrimp inhibition
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