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Diels-Alder Type Adducts from Hairy Root Cultures of Morus macroura

Natural Product Sciences 2019년 25권 3호 p.233 ~ 237
 ( Happyana Nizar ) - Bandung Institute of Technology Faculty of Mathematics and Natural Sciences

 ( Hakim Euis H. ) - Bandung Institute of Technology Faculty of Mathematics and Natural Sciences
 ( Syah Yana M. ) - Bandung Institute of Technology Faculty of Mathematics and Natural Sciences
 ( Kayser Oliver ) - Technical University of Dortmund Department of Technical Biochemistry
 ( Juliawaty Lia D. ) - Bandung Institute of Technology Faculty of Mathematics and Natural Sciences
 ( Mujahidin Didin ) - Bandung Institute of Technology Faculty of Mathematics and Natural Sciences
 ( Ermayanti Tri M. ) - Indonesian Institute of Sciences Research Center for Biotechnology
 ( Achmad Sjamsul A. ) - Bandung Institute of Technology Faculty of Mathematics and Natural Sciences

Abstract


Three Diels-Alder type adducts, guangsangon E (1), chalcomoracin (2) and sorocein I (3) were isolated from hairy root cultures of Morus macroura. The structures of the isolated compounds (1 - 3) were determined by spectroscopic method (NMR and MS), and spectral comparison to literature. Cytotoxic activities of the isolated compounds (1 - 3) were investigated against P-388 murine leukemia cell line. Guangsangon E (1) showed the most potent cytotoxicity against P-388 murine leukemia cell line with IC50 value of 2.75 ± 0.32 μg/ mL. To the best of our knowledge, guangsangon E (1) and sorocein I (3) were reported for the first time from the tissue cultures of M. macroura.

키워드

Diels-Alder type adduct; Morus macroura; tissue cultures; cytotoxicity
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