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Flavestin K, An Isoprenylated Stilbene from the Leaves of Macaranga recurvata Gage

Natural Product Sciences 2019년 25권 3호 p.244 ~ 247
 ( Tjahjandarie Tjitjik Srie ) - Universitas Airlangga Faculty of Science and Technology Department of Chemistry

 ( Tanjung Mulyadi ) - Universitas Airlangga Faculty of Science and Technology Department of Chemistry
 ( Saputri Ratih Dewi ) - Universitas Airlangga Faculty of Science and Technology Department of Chemistry
 ( Nadar Puja Bintu ) - Universitas Airlangga Faculty of Science and Technology Department of Chemistry
 ( Aldin Muhammad Fajar ) - Universitas Airlangga Faculty of Science and Technology Department of Chemistry
 ( Marliana Eva ) - Universitas Mulawarman Faculty of Mathematics and Natural Science Department of Chemistry
 ( Permadi Anton ) - Sekolah Tinggi Ilmu Ekonomi Muara Teweh Department of Management

Abstract


A new isoprenylated stilbene, flavestinK (1) together with two known isoprenylated stilbenes, flavestin B (2), flavestin G (3), and two isoprenilated flavanones, 4-O-methyl-8-isoprenylnaringenin (4) and 8- isoprenyl-5,7-dihydroxyflavanone (5) were isolated from the leaves of Macaranga recurvata Gage. All of the structures have been determined based on HRESIMS, 1D and 2D NMR spectral data. All of the isolated compounds were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D and WiDr). Compound 1 showed higher activity than doxorubicin against HeLa cells with IC50 value of 13.1 μg/mL.

키워드

Flavestin K; Stilbene; Macaranga recurvata; Cytotoxicity
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