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Dioscorea japonica Thunb. Ethanolic Extract Attenuated Oxazolone-Induced Atopic Dermatitis-like Skin Lesions in BALB/c Mice

Natural Product Sciences 2019년 25권 3호 p.261 ~ 267
 ( Jegal Jong-Hwan ) - Pusan National University College of Pharmacy

 ( Park No-June ) - Korea Institute of Science and Technology Natural Products Research Institute
 ( Jo Beom-Geun ) - Pusan National University College of Pharmacy
 ( Kim Su-Nam ) - Korea Institute of Science and Technology Natural Products Research Institute
 ( Yang Min-Hye ) - Pusan National University College of Pharmacy

Abstract


The rhizomes of Dioscorea japonica Thunb. are widely consumed as food and also used to treat diabetes and polyuria in Korea. This study was undertaken to study the anti-atopic dermatitis effects of a 95% ethanolic extract (DJE) of D. japonica in an oxazolone-stimulated murine model of atopic dermatitis (AD). The therapeutic effects of DJE on AD-like skin lesions were assessed on both ears. DJE (1%) or dexamethasone (0.5%; the positive control) were applied to skin lesions for three weeks. Serum levels of IgE and IL-4 were assessed by ELISA (enzyme-linked immunosorbent assay). Histopathological examinations were performed by hematoxylin and eosin (H&E) and toluidine blue staining and revealed DJE significantly reduced dermal thickness and inflammatory cell infiltration when applied to oxazolone-treated ear skin. DJE-treated AD mice also showed lower serum levels of IgE and IL-4 than oxazolone-stimulated controls. Our findings demonstrate DJE might be a useful safe, topical agent for the treatment of atopic diseases.

키워드

Dioscorea japonica Thunb.; Atopic dermatitis; Oxazolone; Interleukin 4
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