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A prognostic index based on an eleven gene signature to predict systemic recurrences in colorectal cancer

Experimental & Molecular Medicine 2019년 51권 10호 p.115 ~ 115
 ( Kim Seon-Kyu ) - Korea Research Institute of Bioscience and Biotechnology Personalized Genomic Medicine Research Center

 ( Kim Seon-Young ) - Korea Research Institute of Bioscience and Biotechnology Genome Editing Research Center
 ( Kim Chan-Wook ) - University of Ulsan College of Medicine Department of Surgery
 ( Roh Seon-Ae ) - University of Ulsan College of Medicine Department of Surgery
 ( Ha Ye-Jin ) - University of Ulsan College of Medicine Department of Surgery
 ( Lee Jong-Lyul ) - University of Ulsan College of Medicine Department of Surgery
 ( Heo Hae-Jeong ) - Korea Research Institute of Bioscience and Biotechnology Personalized Genomic Medicine Research Center
 ( Cho Dong-Hyung ) - Kyungpook National University Graduate School of Life Sciences
 ( Lee Ju-Seog ) - University of Texas MD Anderson Cancer Center Department of Systems Biology
김용성 ( Kim Yong-Sung ) - Korea Research Institute of Bioscience and Biotechnology Genome Editing Research Center
 ( Kim Jin-Cheon ) - University of Ulsan College of Medicine Department of Surgery

Abstract


Approximately half of colorectal cancer (CRC) patients experience disease recurrence and metastasis, and these individuals frequently fail to respond to treatment due to their clinical and biological diversity. Here, we aimed to identify a prognostic signature consisting of a small gene group for precisely predicting CRC heterogeneity. We performed transcriptomic profiling using RNA-seq data generated from the primary tissue samples of 130 CRC patients. A prognostic index (PI) based on recurrence-associated genes was developed and validated in two larger independent CRC patient cohorts (n?=?795). The association between the PI and prognosis of CRC patients was evaluated using Kaplan?Meier plots, log-rank tests, a Cox regression analysis and a RT-PCR analysis. Transcriptomic profiling in 130 CRC patients identified two distinct subtypes associated with systemic recurrence. Pathway enrichment and RT-PCR analyses revealed an eleven gene signature incorporated into the PI system, which was a significant prognostic indicator of CRC. Multivariate and subset analyses showed that PI was an independent risk factor (HR?=?1.812, 95% CI?=?1.342?2.448, P?

키워드

Cancer genomics; Colorectal cancer; Prognostic markers
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