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Nogo receptor?vimentin interaction: a novel mechanism for the invasive activity of glioblastoma multiforme

Experimental & Molecular Medicine 2019년 51권 10호 p.125 ~ 125
 ( Kang Yun-Hee ) - Eulji University School of Medicine Eulji Biomedical Science Research Institute

 ( Han Seung-Ro ) - Eulji University School of Medicine Eulji Biomedical Science Research Institute
 ( Jeon Hyung-Taek ) - Eulji University School of Medicine Department of Microbiology and Immunology
 ( Lee Su-Hyuk ) - Eulji University School of Medicine Department of Microbiology and Immunology
 ( Lee Ji-Su ) - Eulji University School of Medicine Department of Microbiology and Immunology
 ( Yoo Seung-Min ) - Eulji University School of Medicine Department of Microbiology and Immunology
 ( Park Jong-Bae ) - National Cancer Center Specific Organs Cancer Branch
 ( Park Myung-Jin ) - Korea Institute of Radiological and Medical Sciences Research Center for Radio-senescence Divisions of Radiation Cancer Research
 ( Kim Jong-Tae ) - Korea Research Institute of Bioscience and Biotechnology Immunotherapy Convergence Research Center
 ( Lee Hee-Gu ) - Korea Research Institute of Bioscience and Biotechnology Immunotherapy Convergence Research Center
 ( Lee Myung-Shin ) - Eulji University School of Medicine Department of Microbiology and Immunology
 ( Lee Seung-Hoon ) - Eulji University School of Medicine Department of Neurosurgery

Abstract


Nogo receptor (NgR) has been shown to inhibit the migration and invasion of human glioma cells. However, little is known regarding the regulatory mechanisms of NgR in glioblastoma multiforme (GBM). In this study, we propose a novel mechanism that regulates the maturation process of NgR through an interaction with vimentin. The inhibition of TGFβ1 activity by LY2109761 attenuated the migration/invasion of GBM cells by upregulating cell-surface NgR. Conversely, the treatment of GBM cells with TGFβ1 suppressed NgR maturation. We showed that NgR and vimentin interact, which could be a possible mechanism for the suppression of NgR maturation. The knockdown of vimentin suppressed the migration/invasion of GBM cells through the increased maturation of NgR. Finally, TCGA (The Cancer Genome Atlas) analysis also supported the association of NgR and vimentin. The maturation of NgR is regulated by the interaction of vimentin and NgR, which attenuates the invasive activity of GBM, and might be a potential therapeutic target for brain cancer.

키워드

Cell invasion; CNS cancer
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