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The circadian rhythm in intervertebral disc degeneration: an autophagy connection

Experimental & Molecular Medicine 2020년 52권 1호 p.18 ~ 18
 ( Zhang Tai-Wei ) - Fudan University Zhongshan Hospital Department of Orthopedic Surgery

 ( Li Ze-Fang ) - Fudan University Zhongshan Hospital Department of Orthopedic Surgery
 ( Dong Jian ) - Fudan University Zhongshan Hospital Department of Orthopedic Surgery
 ( Jiang Li-Bo ) - Fudan University Zhongshan Hospital Department of Orthopedic Surgery

Abstract


There is one circadian clock in the central nervous system and another in the peripheral organs, and the latter is driven by an autoregulatory molecular clock composed of several core clock genes. The height, water content, osmotic pressure and mechanical characteristics of intervertebral discs (IVDs) have been demonstrated to exhibit a circadian rhythm (CR). Recently, a molecular clock has been shown to exist in IVDs, abolition of which can lead to stress in nucleus pulposus cells (NPCs), contributing to intervertebral disc degeneration (IDD). Autophagy is a fundamental cellular process in eukaryotes and is essential for individual cells or organs to respond and adapt to changing environments; it has also been demonstrated to occur in human NPCs. Increasing evidence supports the hypothesis that autophagy is associated with CR. Thus, we review the connection between CR and autophagy and the roles of these mechanisms in IDD.

키워드

Macroautophagy; Mechanisms of disease; Senescence
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