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ROS in cancer therapy: the bright side of the moon

Experimental & Molecular Medicine 2020년 52권 2호 p.4 ~ 4
 ( Perillo Bruno ) - C.N.R. Istituto di Scienze dell’Alimentazione

 ( Di Donato Marzia ) - Universita della Campania L. Vanvitelli Dipartimento di Medicina di Precisione
 ( Pezone Antonio ) - Universita di Napoli Federico II Dipartimento di Medicina Molecolare e Biotecnologie Mediche
 ( Di Zazzo Erika ) - Universita della Campania L. Vanvitelli Dipartimento di Medicina di Precisione
 ( Giovannelli Pia ) - Universita della Campania L. Vanvitelli Dipartimento di Medicina di Precisione
 ( Galasso Giovanni ) - Universita della Campania L. Vanvitelli Dipartimento di Medicina di Precisione
 ( Castoria Gabriella ) - Universita della Campania L. Vanvitelli Dipartimento di Medicina di Precisione
 ( Migliaccio Antimo ) - Universita della Campania L. Vanvitelli Dipartimento di Medicina di Precisione

Abstract


Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have evolved as regulators of important signaling pathways. It is now well accepted that moderate levels of ROS are required for several cellular functions, including gene expression. The production of ROS is elevated in tumor cells as a consequence of increased metabolic rate, gene mutation and relative hypoxia, and excess ROS are quenched by increased antioxidant enzymatic and nonenzymatic pathways in the same cells. Moderate increases of ROS contribute to several pathologic conditions, among which are tumor promotion and progression, as they are involved in different signaling pathways and induce DNA mutation. However, ROS are also able to trigger programmed cell death (PCD). Our review will emphasize the molecular mechanisms useful for the development of therapeutic strategies that are based on modulating ROS levels to treat cancer. Specifically, we will report on the growing data that highlight the role of ROS generated by different metabolic pathways as Trojan horses to eliminate cancer cells.

키워드

Cancer therapy; Health sciences; Therapeutics
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