잠시만 기다려 주세요. 로딩중입니다.

Small-molecule-mediated reprogramming: a silver lining for regenerative medicine

Experimental & Molecular Medicine 2020년 52권 2호 p.8 ~ 8
김요한 ( Kim Yo-Han ) - Hanyang University College of Medicine Department of Surgery

정재민 ( Jeong Jae-Min ) - Hanyang University College of Medicine Department of Surgery
최동호 ( Choi Dong-Ho ) - Hanyang University College of Medicine Department of Surgery

Abstract


Techniques for reprogramming somatic cells create new opportunities for drug screening, disease modeling, artificial organ development, and cell therapy. The development of reprogramming techniques has grown exponentially since the discovery of induced pluripotent stem cells (iPSCs) by the transduction of four factors (OCT3/4, SOX2, c-MYC, and KLF4) in mouse embryonic fibroblasts. Initial studies on iPSCs led to direct-conversion techniques using transcription factors expressed mainly in target cells. However, reprogramming transcription factors with a virus risks integrating viral DNA and can be complicated by oncogenes. To address these problems, many researchers are developing reprogramming methods that use clinically applicable small molecules and growth factors. This review summarizes research trends in reprogramming cells using small molecules and growth factors, including their modes of action.

키워드

Reprogramming; Transdifferentiation
원문 및 링크아웃 정보
 
등재저널 정보