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Translocator protein (TSPO): the new story of the old protein in neuroinflammation

BMB Reports 2020년 53권 1호 p.20 ~ 27
 ( Lee Young-Hwan ) - Daegu Gyeongbuk Institute of Science and Technology Department of Brain and Cognitive Sciences

 ( Park Young-Jin ) - Daegu Gyeongbuk Institute of Science and Technology Department of Brain and Cognitive Sciences
남혜리 ( Nam Hye-Ri ) - Daegu Gyeongbuk Institute of Science and Technology Department of Brain and Cognitive Sciences
이지원 ( Lee Ji-Won ) - Daegu Gyeongbuk Institute of Science and Technology Department of Brain and Cognitive Sciences
 ( Yu Seong-Woon ) - Daegu Gyeongbuk Institute of Science and Technology Department of Brain and Cognitive Sciences

Abstract


Translocator protein (TSPO), also known as peripheral benzodiazepine receptor, is a transmembrane protein located on the outer mitochondria membrane (OMM) and mainly expressed in glial cells in the brain. Because of the close correlation of its expression level with neuropathology and therapeutic efficacies of several TSPO binding ligands under many neurological conditions, TSPO has been regarded as both biomarker and therapeutic target, and the biological functions of TSPO have been a major research focus. However, recent genetic studies with animal and cellular models revealed unexpected results contrary to the anticipated biological importance of TSPO and cast doubt on the action modes of the TSPO-binding drugs. In this review, we summarize recent controversial findings on the discrepancy between pharmacological and genetic studies of TSPO and suggest some future direction to understand this old and mysterious protein.

키워드

Microglia; Mitochondria; Neuroinflammation; Steroidogenesis; TSPO
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