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Sphingolipids in neuroinflammation: a potential target for diagnosis and therapy

BMB Reports 2020년 53권 1호 p.28 ~ 34
이주연 ( Lee Ju-Youn ) - Kyungpook National University School of Medicine Department of Physiology

진희경 ( Jin Hee-Kyung ) - Kyungpook National University College of Veterinary Medicine Department of Laboratory Animal Medicine
배재성 ( Bae Jae-Sung ) - Kyungpook National University School of Medicine Department of Physiology

Abstract


Sphingolipids are ubiquitous building blocks of eukaryotic cell membranes that function as signaling molecules for regulating a diverse range of cellular processes, including cell proliferation, growth, survival, immune-cell trafficking, vascular and epithelial integrity, and inflammation. Recently, several studies have highlighted the pivotal role of sphingolipids in neuroinflammatory regulation. Sphingolipids have multiple functions, including induction of the expression of various inflammatory mediators and regulation of neuroinflammation by directly effecting the cells of the central nervous system. Accumulating evidence points to sphingolipid engagement in neuroinflammatory disorders, including Alzheimer’s and Parkinson’s diseases. Abnormal sphingolipid alterations, which involves an increase in ceramide and a decrease in sphingosine kinase, are observed during neuroinflammatory disease. These trends are observed early during disease development, and thus highlight the potential of sphingolipids as a new therapeutic and diagnostic target for neuroinflammatory diseases.

키워드

Alzheimer’s disease; Ceramide; Neuroinflammation; Parkinson’s disease; Sphingosine kinase; Sphingosine-1-phosphate
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