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Circular RNA hsa_circ_0075828 Promotes Bladder Cancer Cell Proliferation Through Activation of CREB1

BMB Reports 2020년 53권 2호 p.82 ~ 87
 ( Zhuang Chengle ) - Peking University Shenzhen Hospital Institute of Urology

 ( Huang Xinbo ) - Peking University Shenzhen Hospital Institute of Urology
 ( Yu Jing ) - Peking University Shenzhen Hospital Department of Laboratory Medicine
 ( Gui Yaoting ) - Peking University Shenzhen Hospital Institute of Urology

Abstract


Circular RNAs (circRNAs), one kind of non-coding RNA, have been reported as critical regulators for modulating gene expression in cancer. In this study, microarray analysis was used to screen circRNA expression profiles of bladder cancer (BC) 5637 cells, T24 cells and normal control SV-HUC-1 cells. The data from the microarray showed that hsa_circ_0075828 (named circCASC15) was most highly expressed in 5637 and T24 cells. circCASC15 was highly expressed in BC tissues and cells. Overexpression of circCASC15 was closely associated with BC tumor stage and promoted cell proliferation significantly in vitro and in vivo. Mechanistically, circCASC15 could act as miR-1224-5p sponge to activate the expression of CREB1 to promote cell proliferation in BC. In short, circCASC15 promotes cell proliferation in BC, which might be a new molecular target for BC diagnosis and therapy.

키워드

Bladder cancer; circCASC15; Circular RNA; CREB1; miR-1224-5p
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