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Effects of caloric restriction on the expression of lipocalin-2 and its receptor in the brown adipose tissue of high-fat diet-fed mice

Korean Journal of Physiology & Pharmacology 2019년 23권 5호 p.335 ~ 344
 ( Park Kyung-Ah ) - Gyeongsang National University College of Medicine Department of Anatomy and Convergence Medical Science

 ( Jin Zhen ) - Gyeongsang National University College of Medicine Department of Anatomy and Convergence Medical Science
안형석 ( An Hyeong-Seok ) - Gyeongsang National University College of Medicine Department of Anatomy and Convergence Medical Science
 ( Lee Jong-Youl ) - Gyeongsang National University College of Medicine Department of Anatomy and Convergence Medical Science
 ( Jeong Eun-Ae ) - Gyeongsang National University College of Medicine Department of Anatomy and Convergence Medical Science
 ( Choi Eun-Bee ) - Gyeongsang National University College of Medicine Department of Anatomy and Convergence Medical Science
 ( Kim Kyung-Eun ) - Gyeongsang National University College of Medicine Department of Anatomy and Convergence Medical Science
 ( Shin Hyun-Joo ) - Gyeongsang National University College of Medicine Department of Anatomy and Convergence Medical Science
 ( Lee Jung-Eun ) - Gyeongsang National University College of Medicine Department of Thoracic and Cardiovascular Surgery
 ( Roh Gu-Seob ) - Gyeongsang National University College of Medicine Department of Anatomy and Convergence Medical Science

Abstract


Obesity causes inflammation and impairs thermogenic functions in brown adipose tissue (BAT). The adipokine lipocalin 2 (LCN2) has been implicated in inflammation and obesity. Herein, we investigated the protective effects of caloric restriction (CR) on LCN2-mediated inflammation and oxidative stress in the BAT of high-fat diet (HFD)-fed mice. Mice were fed a HFD for 20 weeks and then either continued on the HFD or subjected to CR for the next 12 weeks. CR led to the browning of the white fat-like phenotype in HFD-fed mice. Increased expressions of LCN2 and its receptor in the BAT of HFD-fed mice were significantly attenuated by CR. Additionally, HFD+CR-fed mice had fewer neutrophils and macrophages expressing LCN2 and iron-positive cells than HFD-fed mice. Further, oxidative stress and mitochondrial fission induced by a HFD were also significantly attenuated by CR. Our findings indicate that the protective effects of CR on inflammation and oxidative stress in the BAT of obese mice may be associated with regulation of LCN2.

키워드

Brown adipose tissue; Caloric restriction; Lipocalin 2; Obesity
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