medric medric
[닫기]
잠시만 기다려 주세요. 로딩중입니다.

Esophageal Motor Dysfunctions in Gastroesophageal Reflux Disease and Therapeutic Perspectives

Journal of Neurogastroenterology and Motility 2019년 25권 4호 p.499 ~ 507
 ( Lin Sihui ) - Chinese Academy of Medical Sciences and Peking Union Medical College Peking Union Medical College Hospital Department of Gastroenterology

 ( Li Hua ) - Xiamen University First Affiliated Hospital Department of Gastroenterology
 ( Fang Xiucai ) - Chinese Academy of Medical Sciences and Peking Union Medical College Peking Union Medical College Hospital Department of Gastroenterology

Abstract


Gastroesophageal reflux disease (GERD) is a very common disease, and the prevalence in the general population has recently increased. GERD is a chronic relapsing disease associated with motility disorders of the upper gastrointestinal tract. Several factors are implicated in GERD, including hypotensive lower esophageal sphincter, frequent transient lower esophageal sphincter relaxation, esophageal hypersensitivity, reduced resistance of the esophageal mucosa against the refluxed contents, ineffective esophageal motility, abnormal bolus transport, deficits initiating secondary peristalsis, abnormal response to multiple rapid swallowing, and hiatal hernia. One or more of these mechanisms result in the reflux of stomach contents into the esophagus, delayed clearance of the refluxate, and the development of symptoms and/or complications. New techniques, such as 24-hour pH and multichannel intraluminal impedance monitoring, multichannel intraluminal impedance and esophageal manometry, high-resolution manometry, 3-dimensional highresolution manometry, enoscopic functional luminal imaging probe, and 24-hour dynamic esophageal manometry, provide more information on esophageal motility and have clarified the pathophysiology of GERD. Proton pump inhibitors remain the preferred pharmaceutical option to treat GERD. The ideal target of GERD treatment is to restore esophageal motility and reconstruct the antireflux mechanism. This review focuses on current advances in esophageal motor dysfunction in patients with GERD and the influence of these developments on GERD treatment.

키워드

Esophageal motility disorders; Esophagogastric junction; Gastroesophageal reflux; Manometry; Pharmaceutical preparations
원문 및 링크아웃 정보
  
등재저널 정보
SCI(E)
KCI
KoreaMed
KAMS