medric medric
[닫기]
잠시만 기다려 주세요. 로딩중입니다.

Association Between Symptoms, Quality of Life, and Gastric Emptying in Dyspeptic Patients

Journal of Neurogastroenterology and Motility 2019년 25권 4호 p.534 ~ 543
 ( Wuestenberghs Fabien ) - Godinne University Hospital Department of Gastroenterology and Hepatology

 ( Juge Mathilde ) - Normandie University Rouen University Hospital Department of Gastroenterology
 ( Melchior Chloe ) - Normandie University Rouen University Hospital Department of Gastroenterology
 ( Desprez Charlotte ) - Normandie University Rouen University Hospital Department of Physiology
 ( Leroi Anne-Marie ) - Normandie University Rouen University Hospital Department of Physiology
 ( Gourcerol Guillaume ) - Normandie University Rouen University Hospital Department of Physiology

Abstract


Background/Aims: Association between symptoms, quality of life and gastric emptying in dyspepsia is inconsistent in the literature. The aim of our study is to investigate if gastric emptying is associated with specific symptoms and quality of life in dyspeptic patients.

Methods: We reviewed retrospectively gastric emptying measured by 13C-labelled octanoate breath testing for more than 6 hours in 198 consecutive patients with dyspepsia complaints. Gastrointestinal symptoms were assessed using a 5-points Likert scale and by a symptomatic composite score, whereas quality of life was measured by the GIQLI.

Results: In our cohort, 90 patients (45%) had a delayed gastric emptying (half emptying time above 166 minutes when assessed over 6-8 hours). There was no difference in symptoms or quality of life between patients with or without delayed gastric emptying. However, patients with severely delayed gastric emptying (half emptying time above 200 minutes) had increased postprandial fullness (P = 0.012), abdominal pain (P = 0.026), bloating (P = 0.044), early satiety (P = 0.018), symptomatic composite score (P = 0.005), and a lower quality of life (P = 0.018). This association was no longer observed if the calculation of gastric emptying was limited to the first 4-hour samples.

Conclusions: There is no association between symptoms, quality of life and gastric emptying in an overall dyspeptic population. However, there is an association between symptoms, quality of life of delayed gastric emptying in the subgroup of patients with severely delayed gastric emptying. An 8-hour measurement of gastric emptying should be recommended.

키워드

Breath tests; Dyspepsia; Gastric emptying; Gastroparesis; Quality of life
원문 및 링크아웃 정보
  
등재저널 정보
SCI(E)
KCI
KoreaMed
KAMS