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비스포스포네이트와 연관된 악골괴사 부골에서의 세균 검출

Detection of bacterial species in the Sequestra of Bisphosphonate-Related Osteonecrosis of the Jaws

대한구강악안면병리학회지 2019년 43권 6호 p.245 ~ 254
전다니 ( Jeon Da-Nee ) - 부산대학교 치의학전문대학원 구강악안면외과학교실

최나래 ( Choi Na-Rae ) - 부산대학교 치의학전문대학원 구강악안면외과학교실
송재민 ( Song Jae-Min ) - 부산대학교 치의학전문대학원 구강악안면외과학교실
신상훈 ( Shin Sang-Hun ) - 부산대학교 치의학전문대학원 구강악안면외과학교실
정진 ( Chung Jin ) - 부산대학교 치의학전문대학원 미생물학교실

Abstract


The purpose of this study was to identify the oral bacterial species in sequestra from patients with bisphosphonate-related osteonecrosis of the jaw (BRONJ). Fifteen patients with BRONJ (2 males and 13 females) were evaluated. Clinical features, radiographic findings, and bisphosphonate intake history were investigated. All patients were treated with surgical methods (curettage or sequestrectomy). Infected bone samples were collected from the affected BRONJ site. Ten bacterial species were selected for polymerase chain reaction (PCR) detection. Two to nine bacterial species were detected by PCR. Gram-negative species were predominant and all identified bacteria were anaerobes. Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola were detected at high levels. These are major pathogenic species in periodontal disease. Orthopantomographic radiographs showed generalized alveolar bone loss in most patients. These radiographic findings may provide evidence of chronic periodontitis as a pre-existing inflammatory disease. Most patients had experienced a predisposing dental procedure, such as tooth extraction. Sequestra (necrotic bone) infected with oral bacterial species may be an important risk factor for BRONJ. As such, prevention and management of BRONJ may rely on effective control of bacteria in the oral cavity.

키워드

BRONJ; Bacteria; Sequestra; Necrotic bone
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