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Antimicrobial activity of Garcinia mangostana L. ethanol extract against Cutibacterium acnes and Staphylococcus aureus

International Journal of Oral Biology 2019년 44권 3호 p.101 ~ 107
임윤경 ( Lim Yun-Kyong ) - Chosun University School of Dentistry Korean Collection for Oral Microbiology and Department of Oral Biochemistry

유소영 ( Yoo So-Young ) - Medi Bio Lab Co. Ltd.
박순낭 ( Park Soon-Nang ) - Chosun University College of Dentistry Korean Collection for Oral Microbiology
이대성 ( Lee Dae-Sung ) - Medi Bio Lab Co. Ltd.
국중기 ( Kook Joong-Ki ) - Chosun University College of Dentistry Korean Collection for Oral Microbiology

Abstract


The purpose of this study was to investigate the antimicrobial activity of the ethanol extract of Garcinia mangostana L. (mangosteen) against Cutibacterium acnes (6 strains) and Staphylococcus aureus (6 strains). The antimicrobial activity of the mangosteen extract was evaluated based on its minimal bactericidal concentration. Cytotoxicity of the mangosteen extract against human embryonic kidney 293 (HEK 293) cells was determined using the cell counting method. The data showed that the mangosteen extract was not toxic to HEK 293 cells at a concentration of up to 16 μg/mL and killed 87.0% and 99.9% of C. acnes and S. aureus after 10 minutes and 1 hour of treatment, respectively.
These results suggest that ethanol extract of mangosteen can be used as an anti-acne agent.

키워드

Garcinia mangostana; Antimicrobial effect; Cutibacterium acnes; Staphylococcus aureus
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