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Preparation and characterization of rutile phase TiO 2 nanoparticles and their cytocompatibility with oral cancer cells

International Journal of Oral Biology 2019년 44권 3호 p.108 ~ 114
 ( Dong Vu Phuong ) - Chosun University College of Dentistry Department of Pharmacology and Dental Therapeutics

 ( Trang Nguyen Thi Kieu ) - Chosun University College of Dentistry Department of Pharmacology and Dental Therapeutics
 ( Yoo Hoon ) - Chosun University College of Dentistry Department of Pharmacology and Dental Therapeutics

Abstract


In the present study, rutile phase titanium dioxide nanoparticles (R-TiO 2 NPs) were prepared by hydrolysis of titanium tetrachloride in an aqueous solution followed by calcination at 900℃. The composition of R-TiO 2 NPs was determined by the analysis of X-ray diffraction data, and the characteristic features of R-TiO 2 NPs such as the surface functional group, particle size, shape, surface topography, and morphological behavior were analyzed by Fourier-transform infrared spectroscopy, scanning electron microscopy and energy dispersive X-ray spectroscopy, transmission electron microscopy, dynamic light scattering, and zeta potential measurements. The average size of the prepared R-TiO 2 NPs was 76 nm, the surface area was 19 m 2 /g, zeta potential was ?20.8 mV, and average hydrodynamic diameter in dimethyl sulfoxide (DMSO)?H 2 O solution was 550 nm. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and morphological observations revealed that R-TiO 2 NPs were cytocompatible with oral cancer cells, with no inhibition of cell growth and proliferation. This suggests the efficacy of R-TiO 2 NPs for the aesthetic white pigmentation of teeth.

키워드

Titanium dioxide nanoparticles; Rutile; Cytocompatibility; FaDu cells; YD-15 cells
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