medric medric
[닫기]
잠시만 기다려 주세요. 로딩중입니다.

Effects of 3,3’,4,4’,5-pentachlorobiphenyl on human Kv1.3 and Kv1.5 channels

International Journal of Oral Biology 2019년 44권 3호 p.115 ~ 123
김종희 ( Kim Jong-Hui ) - Kangwon National University College of Medicine Department of Physiology

 ( Hwang Soo-Been ) - Kangwon National University College of Medicine Department of Physiology
박서인 ( Park Seo-In ) - Kangwon National University College of Medicine Department of Physiology
 ( Jo Su-Hyun ) - Kangwon National University College of Medicine Department of Physiology

Abstract


Among the environmental chemicals that may be able to disrupt the endocrine systems of animals and humans are polychlorinated biphenyls (PCBs), a chemical class of considerable concern. PCB consists of two six-carbon rings linked by a single carbon bond, and theoretically, 209 congeners can form, depending on the number of chlorines and their location on the biphenyl rings. Furthermore, 3,3’,4,4’,5-pentachlorobiphenyl (PCB126) exposure also increases nitric oxide production and nuclear factor kappa-light-chain-enhancer of activated B cells binding activity in chondrocytes, thus contributing as an initiator of chondrocyte apoptosis and resulting in thymic atrophy and immunosuppression. This study identified whether cardiac and immune abnormalities from PCB126 were caused by the Kv1.3 and Kv1.5 channels. PCB126 did not affect either the steady-state current or peak current of the Kv1.3 and Kv1.5 channels. However, PCB126 right-shifted the steady-state activation curves of human Kv1.3 channels. These results suggest that PCBs can affect the heart in a way that does not block voltage-dependent potassium channels including Kv1.3 and Kv1.5 directly.

키워드

3, 3’, 4, 4’, 5-pentachlorobiphenyl; Kv1.3 channel; Kv1.5 channel
원문 및 링크아웃 정보
등재저널 정보