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Effect of the hedgehog signaling pathway on hair formation-related cells

International Journal of Oral Biology 2019년 44권 4호 p.144 ~ 151
박재현 ( Park Jae-Hyun ) - Seoul National University School of Dentistry Dental Research Institute

박상규 ( Park Sang-Kyu ) - Seoul National University School of Dentistry Dental Research Institute Cellular Reprogramming and Embryo Biotechnology Laboratory
서정민 ( Seo Jeong-Min ) - NeoRegen Biotech Co. Ltd. Biomedical Research Institute
노상호 ( Roh Sang-Ho ) - Seoul National University School of Dentistry Dental Research Institute

Abstract


Alopecia has emerged as one of the biggest interests in modern society. Many studies have focused on the treatment of alopecia, such as transplantation of hair follicles or inhibition of the androgen pathway. Hair growth is achieved through proper proliferation of the components such as keratinocytes and dermal papilla cells (DPCs), movement, and interaction between the two cells. The present study examined the effect of the hedgehog (Hh) signaling pathway, which is an important and fundamental signal in the cell, on the morphology and the viability of human keratinocytes and DPCs. Upregulation of Hh signaling caused a morphological change and an increase in epithelium-mesenchymal transition-related gene expression but reduced the viability of keratinocytes, while the alteration of Hh signaling did not cause any change in DPCs. The results show the possibility that the regulation of Hh signaling can be applied for the treatment of alopecia.

키워드

Keratinocytes; Dermal papilla cell; Hedgehog signaling; Epithelial-mesenchymal transition
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