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Apelin-APJ axis inhibits TNF-alpha-mediated expression of genes involved in the inflammatory response in periodontal ligament cells

International Journal of Oral Biology 2019년 44권 4호 p.182 ~ 190
 ( Lee Gyu-Seok ) - Chonnam National University School of Dentistry Department of Pharmacology and Dental Therapeutics

송원현 ( Song Won-Hyun ) - Chonnam National University School of Dentistry Department of Pharmacology and Dental Therapeutics
 ( Kim Su-Jin ) - Chonnam National University School of Dentistry Department of Pharmacology and Dental Therapeutics
 ( Kim Young-Gwon ) - Chonnam National University School of Dentistry Department of Pharmacology and Dental Therapeutics
류제황 ( Ryu Je-Hwang ) - Chonnam National University School of Dentistry Department of Pharmacology and Dental Therapeutics

Abstract


Periodontitis is an inflammatory disease of the supportive tissues surrounding the teeth, and is characterized by irreversible destruction of the gingiva, periodontal ligament (PDL), and alveolar bone, which results in the loss of teeth. In the present study, we elucidated the correlation between periodontitis and apelin (APLN), an adipokine and a regulatory peptide, respectively, which are involved in inflammation and bone remodeling. The expression of APLN is negatively correlated with periodontitis progression in gingival tissue. In addition, treatment with TNF-α downregulated the expression of APLN in PDL cells and gingival fibroblasts, indicating the protective role played by APLN against periodontitis progression. The overexpression of APLN or treatment with exogenous APLN suppressed the TNF-α- mediated catabolic gene expression of MMP1 , IL6 , and PTGS2 in PDL cells. Moreover, the inhibition of the APLN- APJ axis by ML221, an APJ inhibitor, induced catabolic gene expression in PDL cells. Thus, the results of this study provided evidence to support APLN as a regulatory factor of the inflammatory response during periodontitis.

키워드

Apelin; APLN; Periodontal ligament; Periodontitis; Inflammation
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