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열수추출 과정에서 삽주, 백출(큰꽃삽주), 북창출 배합이감초 성분의 추출률에 미치는 영향

Chemical influences of the rhizomes of Atractylodes japonica, A. macrocephala,or A. chinensis on the extraction efficiencies of chemical compounds in the rootsand rhizomes of Glycyrrhiza uralensis during hot-water extraction

대한본초학회지 2019년 34권 5호 p.39 ~ 47
김정훈 ( Kim Jung-Hoon ) - 부산대학교 한의학전문대학원 약물의학부

Abstract


Objectives : When herbal medicines are extracted together, they may interact with each other, leading to change of chemical characteristics. This study aimed to evaluate the influence of Atractylodes rhizomes (Atractylodes japonica, A. macrocephala, and A. chinensis) on the chemical features of the roots and rhizomes of Glycyrrhiza uralensis, which is are commonly combined with herbal medicines in many herbal formulae, when they are co-decocted.

Methods : Liquiritin apioside, liquiritin, ononin, and glycyrrhizin levels of G. uralensis in hot-water extracts prepared by the combination of Atractylodes rhizomes with various weight ratios (G. uralensis : Atractylodes rhizomes = 10:0, 10:5, 10:10, and 10:20) and extraction times (60, 90, and 120 min) were quantified using a HPLC-diode array detector and compared by statistical analysis.

Results : The concentrations of liquiritin apioside, liquiritin, ononin, and glycyrrhizin from G. uralensis roots and rhizomes mostly reduced when co-extracted with Atractylodes rhizomes, and the addition of A. chinensis most reduced their contents between Atractylodes combination groups. A. japonica and A. macrocephala rhizomes also showed differences of liquiritin and glycyrrhizin levels at 10 g and 20 g groups of Atractylodes rhizomes. Extraction times also affected the concentrations of liquiritin, ononin, and glycyrrhizin mostly during 60 and 90 min.

Conclusions : Atractylodes rhizomes might alter the chemical characteristics of G. uralensis when these herbs are co-decocted. This study provides the understanding of the chemical interactions of herbal medicines during the extraction in hot water.

키워드

Atractylodes japonica; A. macrocephala; A. chinensis; Glycyrrhiza uralensis; chemical interaction; hot-water extraction
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