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혈청 아밀로이드 P (SAP)의 정상 참고치 탐색을 위한 문헌 고찰

Reference value of serum amyloid P : a systematic review

대한예방한의학회지 2019년 23권 2호 p.91 ~ 99
박선주 ( Park Sun-Ju ) - 대전대학교 한의과대학 예방의학교실

정지연 ( Jung Jee-Youn ) - 한국한의학연구원 임상의학부
장수빈 ( Jang Soo-Bin ) - 한국한의학연구원 임상의학부

Abstract


Objectives : The aim of this study was to examine the reference value of biomarker serum amyloid p (SAP) to diagnose blood stasis objectively.

Methods : Pubmed-Medline, Cochrane library, EMBASE were searched using the key words ‘SAP’ and ‘serum amyloid p’ in June 2018. Original articles of human adults that published in English, studies that recruited from the clinical research settings or well defined population based cohorts were only included.

Results : A total of 12 studies were selected to extract the reference value of SAP. It was between 8.5 ng/mL (0.0085 mg/L) to 57.5 mg/L. Although the disease varied, most of them showed elevated SAP levels in the disease group (1.1-1.5 times).

Conclusions : This study is meaningful in that it summarizes the results of previous researches of SAP, which has the potential to be diagnostic index of blood stasis.

키워드

serum amyloid P; SAP; blood stasis; biomarker; reference value; reference range
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