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장단기 고용량 카페인 투여가 청소년기 동물모델의 행동에 미치는 영향

Influence of short- and long-term high-dose caffeine administration on behavior in an animal model of adolescence

Journal of Korean Biological Nursing Science 2019년 21권 3호 p.217 ~ 223
박종민 ( Park Jong-Min ) - 경희대학교 간호과학대학

김윤주 ( Kim Yoon-Ju ) - 경희대학교 간호과학대학
김하은 ( Kim Ha-Eun ) - 경희대학교 간호과학대학
 ( Kim Youn-Jung ) - 경희대학교 간호과학대학


Purpose: Caffeine is the most widely consumed psychostimulant of the methylxanthine class. Among adolescents, high-dose of caffeine consumption has increased rapidly over the last few decades due to the introduction of energy drinks. However, little is known about the time-dependent effect of high doses of caffeine consumption in adolescents. The present study aims to examine the short- and long-term influence of high-dose caffeine on behavior of adolescence.
Methods: The animals were divided into three groups: a “vehicle” group, which was injected with 1 ml of phosphate-buffered saline for 14 days; a “Day 1” group, which was injected with caffeine (30 mg/kg), 2 h before the behavioral tests; and a “Day 14” group, which was infused with caffeine for 14 days. An open-field test, a Y-maze test, and a passive avoidance test were conducted to assess the rats’activity levels, anxiety, and cognitive function.

Results: High-dose caffeine had similar effects in short-and long-term treatment groups. It increased the level of locomotor activity and anxiety-like behavior, as evidenced by the increase in the number of movements and incidences of rearing and grooming in the caffeine-treated groups. No significant differences were observed between the groups in the Y-maze test. However, in the passive avoidance test, the escape latency in the caffeine-treated group was decreased significantly, indicating impaired memory acquisition.

Conclusion: These results indicate that high-dose caffeine in adolescents may increase locomotor activity and anxiety-like behavior and impair learning and memory, irrespective of the duration of administration. The findings will be valuable for both evidence-based education and clinical practice.


카페인; 청소년; 활동; 불안; 기억
Caffeine; Adolescent; Locomotion; Anxiety; Memory
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