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시호의 약리효능과 화학성분에 대한 한의학적 고찰

The study on chemical compound and traditional medical effect of Bupleurum falcatum L

제한동의학술원논문집 2013년 11권 1호 p.15 ~ 25
정성효 ( Jung Sung-Hyo ) - 대구한의대학교 한의학과 본초학교실

노성수 ( Roh Seong-Soo ) - 대구한의대학교 한의학과 본초학교실

Abstract


Objects: This study was conducted to investigate the pharmacological effect and its chemical compound in Bupleurum falcatum L.

Methods: First, we searched books, research paper, internet site. Second, we researched keyword: Bupleurum flacatum, effect, chemical, compound, extract, saikosaponin A, Bl, B2, B3, B4, C, D, el, H, I, a-spinasterol, stigmasterol, bupleurmol, eugenol, hexoic, v-lactone undecylate, p-methoxy phenyl diketone, olecic acid, linolenic acid, palmitic acid, stearic acid, polysaccharide, alkaloids, glucose, amino acid. Third, Keywords arrangement a pharmacological effects extract of Bupfeurum fi1fcatum, chemical compound of Bupleurum falcatum, fraction of Bupleurum falcatum.

Results: First Pharmacological action of the crude extract of Bupleurum anti-foam ceil formation, hypothyroidism improvement, improvement of ischemic stroke symptoms, inhibited acute lung injury, anti-inflammatory bowel disease, damage to the sciatic nerve axon regeneration Crush improvement action is reactive. The second, Bupleurum falcatum extract fractions have VCAM-l/VLA-4 inhibitory effect, liver damage recovery effects. Third, Bupleurum falcatum pharmacological efficacy of the ingredients of the GABA-B receptor through reducing the reinforcing effects of morphine, liver damage, depression, suppression of urine protein excretion, increased serum cholesterol, inhibit the increase of serum corticosterone, hamam effects in osteoarthritis cartilage damage reduction, improvement of blood lipid peroxidation and liver damage has been reported suppression. Fourth, Bupleurum falcatum of beneficient an oriental sympotom are inhibit liver damage, ischemic stroke improvement, anti-inflammatory bowel disease is suppressed.

Conc1usion: These chemical compounds and extract of Bupleurum falcatum L. may be used several disease. The effect of gangiwoolkeol and talhang can be explained, but others were insufficient data available on efficacy. Furthermore, resear.ch is need.

키워드

Bupleurum falcatum L; chemical compound; saikosaponin; stigmasterol; eugenol; extract fraction
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