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약물에 대한 쥐의 초음파 발성의 경향성

Tendency of ultrasonic vocalizations (USVs) about drugs in Rat

제한동의학술원논문집 2015년 13권 1호 p.1 ~ 7
김도희 ( Kim Do-Hee ) - 대구한의대학교 한의예과 생리학교실

김희영 ( Kim Hee-Young ) - 대구한의대학교 한의예과 생리학교실

Abstract


Ultrasonic vocalizations (USVs) may index the emotional states in rats, and 50-kHz USVs have been proposed as a tool to investigate the rewarding properties of drugs. Apart from the evidence on some psychostimulants, little is known about the effects of other drugs with rewarding properties on emission of 50-kHz USVs. To further elucidate the neuropharmacology of 50-kHz USVs and their relevance in drug-induced reward, this study characterized the effects of different drugs possessing rewarding properties on 50-kHz USVs in adult male rats. Rats received the acute administration of cocaine (15 mg/kg, i.p.), methamphetamine (2.5 mg/kg, i.p.), morphine (10 mg/kg, i.p.), or nicotine (0.6 mg/kg, s.c.). The number of 50-kHz USVs measured. Cocaine, methamphetamine, nicotine increased the total number of 50-kHz USVs emitted by rats. Conversely, morphine did not elevate the total number of 50-kHz USVs. This study demonstrates that major differences exist in the effects of psychoactive drugs on 50-kHz USVs in rats. These findings provide a better understanding of psychoactive properties of drugs with rewarding properties and usefulness of 50-kHz USVs in assessment of these properties.

키워드

Ultrasonic vocalizations; drugs
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