medric medric
잠시만 기다려 주세요. 로딩중입니다.

Molecular genomic characterization of severe fever with thrombocytopenia syndrome virus isolates from South Korea

Journal of Microbiology 2019년 57권 10호 p.927 ~ 937
 ( Won Yu-Jung ) - Catholic University College of Medicine Department of Microbiology

 ( Kang Lae-Hyung ) - Catholic University College of Medicine Department of Microbiology
 ( Lee Sung-Geun ) - Chonbuk National University Korea Zoonosis Research Institute
 ( Park Seung-Won ) - Daegu Catholic University Department of Biotechnology
 ( Han Jae-Ik ) - Chonbuk National University College of Veterinary Medicine Laboratory of Wildlife Diseases
 ( Paik Soon-Young ) - Catholic University College of Medicine Department of Microbiology


Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne emerging infectious disease caused by the SFTS virus (SFTSV) and is a threat to public health due to its high fatality rate. However, details on tick-to-human transmission of SFTSV are limited. In this study, we determined the whole-genome sequence of a South Korean SFTSV strain (CUK-JJ01), compared it to those of other recent human SFTSV isolates, and identified the genetic variations and relationships among the SFTSV strains. The genome of CUK-JJ01 was consistent with the genome of other members of the genus Phlebovirus, including the large (L), medium (M), and small (S) segments of 6368, 3378, and 1744 nucleotides, respectively. Based on amino acid sequences of the M and S segments, which are used to distinguish the six SFTSV genotypes, CUK-JJ01 was classified as genotype B. Segment analysis revealed that the L, M, and S segments were 97.49%, 97.18%, and 97.94% similar to those of KAJNH2/2013/Korea, ZJZHSH-FDE/2012/China, and KADGH/2013/Korea, respectively. Currently, only few studies on SFTSV have been conducted in Korean population and most were limited to serological analysis. Although the present study has limitations in terms of number of sample analyzed, the findings may serve as basis to understand the transmission and spread of SFTSV, as well as for the development of diagnostic and detection methods for viral recombinants by comparing the whole genome sequence of SFTSV isolates from South Korea and that of foreign isolates.


SFTS; SFTSV; whole-genome sequencing; Phlebovirus; South Korea; phylogeny
원문 및 링크아웃 정보
등재저널 정보