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Coronary-to-Pulmonary Artery Fistula in Adults: Natural History and Management Strategies

Korean Journal of Radiology 2019년 20권 11호 p.1491 ~ 1497
 ( Kim Ho-Kun ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Radiology

 ( Beck Kyong-Min Sarah ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Radiology
 ( Choe Yeon-Hyeon ) - Sungkyunkwan University School of Medicine Samsung Medical Center Department of Radiology
정정임 ( Jung Jung-Im ) - Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Radiology


Objective: To evaluate the natural course of coronary-to-pulmonary artery fistula (CPAF) detected on coronary computed tomography angiography (CCTA) and to propose potential treatment strategies.

Materials and Methods: In this retrospective multicenter study, we assessed the CCTA reports of 188 CPAF patients evaluated between March 2009 and June 2016. Fifty-seven patients were excluded because their follow-up (FU) periods were less than 2 years. Information regarding demographic characteristics, past history, treatment method, and the occurrence of major adverse cardiac events (MACE) during the FU period was collected. We analyzed the morphologic features of CPAF and the various factors associated with surgical treatment. Patients who had undergone FU CCTA after being diagnosed with CPAF were assessed for the presence of morphological changes on FU imaging.

Results: The median age of the study population was 63.0 years (range, 57.0?72.0 years), and the median FU period was 5.72 years (range, 4.08?6.96 years). The most common origin of the CPAF was both coronary arteries in 76 (58.0%) cases. An aneurysm or aneurysms was/were present in 41 (31.3%) cases. Fifty-four (41.2%) fistulas were less than 2 mm in size. Eight patients underwent surgery, and 123 (93.9%) patients received optimal medical treatment (OMT). The fistula size was significantly different between the two treatment groups (p = 0.013) and was the only factor associated with surgical treatment (odds ratio = 1.14, p = 0.021). Only one patient in the OMT group reported MACE during the FU period due to preexisting coronary artery disease. Twenty-nine patients (22.1%) underwent FU CCTA after CPAF diagnosis, with a median FU period of 3.81 years. None of the patients in the OMT group demonstrated morphological changes in the CPAF on FU imaging.

Conclusion: Most CPAFs identified on CCTA have a favorable prognosis. Observation with OMT is usually an appropriate strategy. Fistula size is a possible determinant for surgical treatment.


CT angiography; Coronary artery; Pulmonary artery; Vascular fistula; Prognosis; Coronary artery anomaly
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