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Scavenger Receptor Class A to E Involved in Various Cancers

Chonnam Medical Journal 2020년 56권 1호 p.1 ~ 5
류순효 ( Ryu Sun-Hyo ) - Boston University School of Medicine

 ( Howland Amanda ) - University of Colorado Denver School of Medicine
 ( Song Brendon ) - University of Denver
 ( Youn Cha-Kyung ) - Chosun University School of Medicine Department of Biomedical Science
 ( Song Peter I. ) - InClinica

Abstract


Scavenger receptors typically bind to multiple ligands on a cell surface, including endogenous and modified host-derived molecules and microbial pathogens. They promote the elimination of degraded or harmful substances such as non-self or altered-self targets through endocytosis, phagocytosis, and adhesion. Currently, scavenger receptors are subdivided into eight classes based on several variations in their sequences due to alternative splicing. Since recent studies indicate targeting scavenger receptors has been involved in cancer prognosis and carcinogenesis, we will focus on the current knowledge about the emerging role of scavenger receptor classes A to E in cancer progression.

키워드

Scavenger Receptor; Scavenger Receptor Class A; Macrophages; Lectin-Like Oxidized LDL Receptor 1
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