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Differential Activation of Macrophages Based on Their Environment in Advanced Age

Chonnam Medical Journal 2020년 56권 1호 p.12 ~ 19
 ( Lee Da-Young ) - Chonnam National University Medical School Department of Biochemistry

임재성 ( Lim Jae-Sung ) - Chonnam National University Medical School Department of Biochemistry
조경아 ( Cho Kyung-A ) - Chonnam National University Medical School Department of Biochemistry

Abstract


The macrophage displays functional and phenotypic diversity, which appears, in no small part, to stem from the ability of macrophages to adapt functionally to changes in their tissue microenvironment. Here, we describe the differential activity of peritoneal macrophages with or without the presence of thioglycollate (TG), an inflammatory drug that encouraged the recruitment of macrophages, during aging. The peritoneal-resident macrophages dramatically reduced in phagocytosis and pro-inflammatory cytokines secretion with aging, whereas the functions of macrophages recruited by TG were not significantly changed with aging. These results suggest that macrophages may be changed by their environment in advanced age, and could provide possible explanations for the controversial results regarding differential changes in macrophages in other papers.

키워드

Macrophages; Thioglycollate; Inflammation; Environment
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