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비만의 진단과 바이오마커

Diagnosis of Obesity and Related Biomarkers

대한내과학회지 2019년 94권 5호 p.414 ~ 424
 ( Bang Chang-Seok ) - 한림대학교 의과대학 내과학교실

오정환 ( Oh Jung-Hwan ) - 가톨릭대학교 의과대학 내과학교실

Abstract


Obesity is associated with various comorbidities, such as type II diabetes, hypertension, dyslipidemia, and cardiovascular disease. Gastrointestinal complications are also frequent and obesity is a direct cause of nonalcoholic fatty liver disease, and are risk factors for gastroesophageal reflux disease, pancreatitis, gallstone disease, diarrhea, dyssynergic defection, and various gastrointestinal cancers. Diagnosis is usually made by measuring body mass index (BMI). Although BMI is correlated with body fat mass, it may overestimate subjects with high muscle mass and underestimate subjects with low muscle mass. Co-measurement of waist circumference as a reflection of abdominal obesity for subjects with BMIs ranging from 25 to 35 kg/m2 has been recommended; however, it is still an anthropometric diagnosis that does not clearly discriminate subjects at risk for developing comorbidities. Biomarkers reflect the underlying biological mechanisms of obesity and can be used to characterize the obesity phenotype (i.e., at high risk for disease development) as well as a target for disease-causing factors. In this article, we describe the conventional diagnosis, biomarkers of obesity, and current challenges.

키워드

바이오마커; 진단; 위장관 질환; 비만
Biomarkers; Diagnosis; Gastrointestinal diseases; Obesity
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