잠시만 기다려 주세요. 로딩중입니다.

Autophagy, Cellular Aging and Age-related Human Diseases

Experimental Neurobiology 2019년 28권 6호 p.643 ~ 657
전소영 ( Cheon So-Yeong ) - Yonsei University College of Medicine Department of Anatomy

 ( Kim Hyun-Jeong ) - Yonsei University College of Medicine Department of Anatomy
 ( Rubinsztein David C. ) - University of Cambridge Cambridge Institute for Medical Research Department of Medical Genetics
이종은 ( Lee Jong-Eun ) - Yonsei University College of Medicine Department of Anatomy

Abstract


Macroautophagy/autophagy is a conserved degradation system that engulfs intracytoplasmic contents, including aggregated proteins and organelles, which is crucial for cellular homeostasis. During aging, cellular factors suggested as the cause of aging have been reported to be associated with progressively compromised autophagy. Dysfunctional autophagy may contribute to age-related diseases, such as neurodegenerative disease, cancer, and metabolic syndrome, in the elderly. Therefore, restoration of impaired autophagy to normal may help to prevent age-related disease and extend lifespan and longevity. Therefore, this review aims to provide an overview of the mechanisms of autophagy underlying cellular aging and the consequent disease. Understanding the mechanisms of autophagy may provide potential information to aid therapeutic interventions in age-related diseases.

키워드

Autophagy; Aging; DNA damage; Oxidative stress; Telomere shortening; SASP
원문 및 링크아웃 정보
 
등재저널 정보