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B Cell Immunophenotyping and Transcriptional Profiles of Memory B Cells in Patients with Myasthenia Gravis

Experimental Neurobiology 2019년 28권 6호 p.720 ~ 726
민영기 ( Min Young-Gi ) - Seoul National University Hospital Department of Neurology

 ( Park Canaria ) - Seoul National University College of Medicine Neuroscience Research Institute
권영남 ( Kwon Young-Nam ) - Seoul National University Hospital Department of Neurology
신제영 ( Shin Je-Young ) - Seoul National University Hospital Department of Neurology
성정준 ( Sung Jung-Joon ) - Seoul National University Hospital Department of Neurology
홍윤호 ( Hong Yoon-Ho ) - SMG-SNU Boramae Medical Center Department of Neurology

Abstract


Myasthenia gravis (MG) is an autoimmune neuromuscular junction disorders mediated by various autoantibodies. Although most patients with MG require chronic immunosuppressive treatment to control disease activity, appropriate surveillance biomarkers that monitor disease activity or potential toxicity of immunosuppressants are yet to be developed. Herein, we investigated quantitative distribution of peripheral blood B cell subsets and transcriptional profiles of memory B cells (CD19+ CD27+) in several subgroups of MG patients classified according to the Myasthenia Gravis Foundation of America (MGFA) Clinical Classification. This study suggests potential immunologic B-cell markers that may guide treatment decision in future clinical settings.

키워드

Myasthenia gravis; B-lymphocytes; Biomarkers; Flow cytometry; Transcriptome
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