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Pharmacokinetics/Pharmacodynamics models of veterinary antimicrobial agents

Journal of Veterinary Science 2019년 20권 5호 p.40 ~ 40
 ( Luo Wanhe ) - Huazhong Agricultural University National Reference Laboratory of Veterinary Drug Residues

 ( Chen Dongmei ) - Huazhong Agricultural University MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products
 ( Wu Mengru ) - Huazhong Agricultural University MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products
 ( Li Zhenxia ) - Huazhong Agricultural University National Reference Laboratory of Veterinary Drug Residues
 ( Tao Yanfei ) - Huazhong Agricultural University MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products
 ( Liu Qianying ) - Huazhong Agricultural University MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products
 ( Pan Yuanhu ) - Huazhong Agricultural University National Reference Laboratory of Veterinary Drug Residues
 ( Qu Wei ) - Huazhong Agricultural University National Reference Laboratory of Veterinary Drug Residues
 ( Yuan Zonghui ) - Huazhong Agricultural University National Reference Laboratory of Veterinary Drug Residues
 ( Xie Shuyu ) - Huazhong Agricultural University National Reference Laboratory of Veterinary Drug Residues

Abstract


Misuse and abuse of veterinary antimicrobial agents have led to an alarming increase in bacterial resistance, clinical treatment failure, and drug residues. To address these problems, consistent and appropriate dosage regimens for veterinary antimicrobial agents are needed. Pharmacokinetics/Pharmacodynamics (PK/PD) models have been widely used to establish rational dosage regimens for veterinary antimicrobial agents that can achieve effective prevention and treatment of bacterial diseases and avoid the development of bacterial resistance. This review introduces building methods for PK/PD models and describes current PK/PD research progress toward rational dosage regimens for veterinary antimicrobial agents. Finally, the challenges and prospects of PK/PD models in the design of dosage regimens for veterinary antimicrobial agents are reviewed. This review will help to increase awareness of PK/PD modeling among veterinarians and hopefully promote its development and future use.

키워드

PK/PD models; dosage regimens; drug residues; bacterial infections; antimicrobial agents
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