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Sedative, analgesic, behavioral and clinical effects of intravenous nalbuphine-xylazine combination in camels (Camelus dromedarius)

Journal of Veterinary Science 2019년 20권 5호 p.55 ~ 55
 ( Khalil Ahmed H. ) - Benha University Faculty of Veterinary Medicine Department of Veterinary Surgery, Anaesthesiology and Radiology

 ( Al-Galil Atef S. Abd ) - Menofiya University Faculty of Veterinary Medicine Department of Veterinary Surgery, Anaesthesiology and Radiology
 ( Sabek Ahmed A. ) - Benha University Faculty of Veterinary Medicine Department of Veterinary Hygiene and Management
 ( Zeineldin Mohamed M. ) - Benha University Faculty of Veterinary Medicine Department of Animal Medicine
 ( Abo-Kora Seham Y. ) - Benha University Faculty of Veterinary Medicine Department of Pharmacology

Abstract


This study examined the sedative, analgesic, behavioral, and clinical effects of a combination of xylazine (XY) and nalbuphine-xylazine (NA-XY) in camels. A total of five adult camels were used in a prospective randomized cross-over design with a wash out period of two weeks. Camels were allocated randomly to two treatment groups: the XY group (xylazine, 1.1mL/100 kg IV) and the NA-XY group (xylazine, 1.1mL/100 kg IV and nalbuphine, 1 mg/kg IV). The sedative, analgesic, behavioral, and clinical effects of XY and NA-XY combination were evaluated prior to administration (baseline) and at 5, 15, 30, 45, 60, 75, 90, and 120 minutes post-administration. The results showed that the NA-XY combination accelerates the onset of sedation and analgesia and prolongs the durations of both sedation (p < 0.001) and analgesia (p < 0.01). The behavioral parameters showed higher scores with a NA-XY combination than xylazine alone. Although a XY injection resulted in a significant decline in the heart and respiratory rate, the NA-XY combination group revealed a non-significant change in both clinical parameters compared to the baseline. In conclusion, the use of a NA-XY combination in camels improved the sedative and analgesic onset and duration with an improved outcome in the behavioral scores, as well as in both the heart and respiratory rates compared to XY alone.

키워드

Analgesia; behavior; camel; nalbuphine-xylazine combination; sedation
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