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A retrospective study of theophylline-based therapy with tracheal collapse in small-breed dogs: 47 cases (2013?2017)

Journal of Veterinary Science 2019년 20권 5호 p.57 ~ 57
 ( Jeung So-Young ) - Seoul National University College of Veterinary Medicine Department of Veterinary Clinical Sciences

 ( Sohn Sang-June ) - Seoul National University College of Veterinary Medicine Department of Veterinary Clinical Sciences
 ( An Ju-Hyun ) - Seoul National University College of Veterinary Medicine Department of Veterinary Clinical Sciences
 ( Chae Hyung-Kyu ) - Seoul National University College of Veterinary Medicine Department of Veterinary Clinical Sciences
 ( Li Qiang ) - Seoul National University College of Veterinary Medicine Department of Veterinary Clinical Sciences
 ( Choi Min-Cheol ) - Seoul National University College of Veterinary Medicine Department of Veterinary Clinical Sciences
 ( Yoon Jung-Hee ) - Seoul National University College of Veterinary Medicine Department of Veterinary Clinical Sciences
 ( Song Woo-Jin ) - Seoul National University College of Veterinary Medicine Department of Veterinary Clinical Sciences
 ( Youn Hwa-Young ) - Seoul National University College of Veterinary Medicine Department of Veterinary Clinical Sciences

Abstract


Theophylline acts as a bronchodilator and has an anti-inflammatory effect. In addition, theophylline can be applied in patients where there are concerns regarding the side-effects of corticosteroids. This retrospective case series evaluated theophylline-based therapy in tracheal collapse (TC) canine patients. Forty-seven dogs with TC that received theophylline-based therapy during 2013?2017 were investigated. A fluoroscopic examination was performed to diagnose and grade TC. Theophylline was prescribed (7.5?30 mg/kg PO q12h) and the theophylline serum concentrations were measured. Coughing was assessed using a coughing scoring scale. The mean coughing score decreased after the theophylline-based therapy compared with that observed before treatment. Clinical improvements were observed in 46/47 patients (97.9%). As the intrathoracic TC grading increased, the final theophylline dosage also increased (p value 0.019). The symptom-free period (SFP) with therapy was 189.7 ± 194.45 days (range, 0?720 days) and there was no statistically significant correlation between the SFP and age, sex, or TC grade on fluoroscopy. Although theophylline has generally been used as a third-line treatment, it was used as the main treatment in this study and most patients showed improvements. Dogs have a wider therapeutic index of serum concentrations than humans, and any undesirable effects were easily overcome. With further research, this therapy may prove to be a useful approach, but its safety for long-term use in the treatment of canine TC patients needs to be established.

키워드

Trachea collapse; small breed dogs; fluoroscopy; theophylline; symptom-free period
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